{"id":52464,"date":"2025-04-25T22:02:15","date_gmt":"2025-04-26T02:02:15","guid":{"rendered":"https:\/\/www.hancockhealth.org\/mayo-health-library\/x-linked-agammaglobulinemia\/"},"modified":"2026-02-04T12:05:40","modified_gmt":"2026-02-04T17:05:40","slug":"x-linked-agammaglobulinemia","status":"publish","type":"mayo","link":"https:\/\/www.hancockhealth.org\/ja\/mayo-health-library\/x-linked-agammaglobulinemia\/","title":{"rendered":"X-linked agammaglobulinemia"},"content":{"rendered":"<div class=\"container mx-auto   wordpress-block wordpress- core-\">\n<p>X-linked agammaglobulinemia (a-gam-uh-glob-u-lih-NEE-me-uh), also called XLA, is an immune system disorder that&#8217;s passed through families, called inherited. <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> makes it hard to fight infections. People with <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> might get infections of the inner ear, sinuses, respiratory tract, bloodstream and internal organs.<\/p>\n<p><abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> almost always affects males. But females can carry the genes linked to the condition. Most people with <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> are diagnosed in infancy or early childhood, after they&#8217;ve had repeated infections. Some people aren&#8217;t diagnosed until they&#8217;re adults.<\/p>\n<p>Most babies with <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> appear healthy for the first few months. They&#8217;re protected by the proteins called antibodies they got from their mothers before birth.<\/p>\n<p>When these antibodies leave their systems, the babies begin to get repeat bacterial infections. The infections can be life-threatening. Infections might involve the ears, lungs, sinuses and skin.<\/p>\n<p>Male infants born with <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> have:<\/p>\n<ul>\n<li>Very small tonsils.<\/li>\n<li>Small or no lymph nodes.<\/li>\n<\/ul>\n<p>X-linked agammaglobulinemia is caused by a change in a gene. People with the condition can&#8217;t produce proteins called antibodies that fight infection. About 40% of people with the condition have a family member who has it.<\/p>\n<p>People with <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> can live mostly typical lives. They should try to take part in regular activities for their ages. But repeat infections linked to <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> will likely need careful watching and treatment. They can damage organs and be life-threatening.<\/p>\n<p>Possible complications include:<\/p>\n<ul>\n<li>Long-lasting, called chronic, lung disease.<\/li>\n<li>Increased risk of certain cancers.<\/li>\n<li>Infectious arthritis.<\/li>\n<li>Increased risk of central nervous system infections from live vaccines.<\/li>\n<\/ul>\n<p>Diagnosis involves a medical history of repeat infections and a physical exam. Blood tests and maybe genetic testing can confirm the diagnosis.<\/p>\n<p>There&#8217;s no cure for <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr>. Treatment aims at boosting the immune system to prevent infections. There also is quick treatment for infections as they happen.<\/p>\n<h3>Medications<\/h3>\n<p>Medicines to treat <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> include:<\/p>\n<ul>\n<li>\n<p><strong>Gammaglobulin.<\/strong> This is a type of protein found in blood that contains antibodies against infections. It&#8217;s put into a vein, called infusion, every 2 to 4 weeks or given with weekly shots.<\/p>\n<p>Reactions to gammaglobulin can include headache, chills, backache and nausea. Reactions are more likely to happen during a viral infection, such as a cold.<\/p>\n<\/li>\n<li><strong>Antibiotics.<\/strong> Some people with <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr> take antibiotics all the time to prevent infections. Others take antibiotics for bacterial infections longer than do people without <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr>.<\/li>\n<\/ul>\n<p>Your healthcare professional likely will suggest that you have follow-up visits every 6 to 12 months to screen for complications of <abbr title=\"X-linked agammaglobulinemia\">XLA<\/abbr>. You&#8217;ll also likely be told to not get live vaccines, such as live polio, measles-mumps-rubella or chickenpox vaccines.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>This genetic disease weakens the immune system, mainly in males, and leads to having infections often.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","tags":[1685,1682],"class_list":["post-52464","mayo","type-mayo","status-publish","hentry","tag-condition","tag-person-group-concept","content_type-diseases-conditions"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>X-linked agammaglobulinemia - Hancock Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.hancockhealth.org\/ja\/mayo-health-library\/x-linked-agammaglobulinemia\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"X-linked agammaglobulinemia - 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