{"id":8359,"date":"2018-10-04T00:00:44","date_gmt":"2018-10-04T04:00:44","guid":{"rendered":"http:\/\/www.hancockregionalhospital.org\/?p=8359"},"modified":"2018-10-04T00:00:44","modified_gmt":"2018-10-04T04:00:44","slug":"consumer-genetic-testing-and-breast-cancer-risk-what-the-tests-actually-tell-us","status":"publish","type":"post","link":"https:\/\/www.hancockhealth.org\/fr\/2018\/10\/consumer-genetic-testing-and-breast-cancer-risk-what-the-tests-actually-tell-us\/","title":{"rendered":"Tests g\u00e9n\u00e9tiques grand public et risque de cancer du sein\u00a0: ce que les tests nous disent r\u00e9ellement"},"content":{"rendered":"
You\u2019ve probably seen the ads: You order a genetic testing kit, mail back a small sample of your DNA, and receive a small website\u2019s worth of information about your ancestry, your distant relatives around the globe, and even how much Neanderthal DNA you have.<\/span><\/p>\n

And increasingly, these consumer-facing genetic tests can tell you about risk factors associated with your health. Just this spring, one major testing company, 23andMe, received <\/span>approval from the FDA<\/span><\/a> to report on three different mutations of the BRCA1 and BRCA2 genes. Mutations to these genes can indicate increased risk of breast cancer in women, and increased risk of breast and prostate cancer in men. In addition to detecting these cancer-related mutations, 23andMe\u2019s Health + Ancestry testing offers information about the risks of Parkinson\u2019s disease, late-onset Alzheimer\u2019s disease, celiac disease, and other, less common diseases and disorders.<\/span><\/p>\n

Health systems like Hancock Health offer <\/span>low-cost labs and testing of many types.<\/span><\/a> And there\u2019s a lot of <\/span>important health information<\/span><\/a> to be gleaned from knowing what\u2019s in your blood and in your cells. <\/span><\/p>\n

But the health testing provided by direct-to-consumer DNA tests like 23andMe has some pretty important fine print. Here are just a few of the things you should consider if you\u2019re thinking of buying your own direct-to-consumer genetic test:<\/span><\/p>\n

It Can\u2019t Say For Sure That You <\/b>Will<\/i><\/b> Develop Certain Diseases or Conditions<\/b><\/h2>\n

Direct-to-consumer tests, like all genetic tests, occasionally generate false positives (showing risks that aren\u2019t really there) and false negatives (failing to show risks that are there). Even when the tests are accurate, they show only your <\/span>risk.<\/span><\/i> A positive result for the genetic variant related to Parkinson\u2019s disease, for example, may mean that you\u2019re more likely than some to develop the disease. It\u2019s not a guarantee that you will. <\/span><\/p>\n

It Can\u2019t Say For Sure That You <\/b>Won\u2019t<\/i><\/b> Develop Certain Diseases or Conditions<\/b><\/h2>\n

Again, everyone taking any genetic test should know that false negatives and false positives happen. And while certain genetic variants have been linked with the development of diseases, other factors\u2014and other genes\u2014often play a part that the tests don\u2019t evaluate.<\/span><\/p>\n

The Breast Cancer Tests Aren\u2019t Relevant for Everyone<\/b><\/h2>\n

Since getting FDA approval, 23andMe\u2019s Health + Ancestry package does test for three of the most common BRCA1\/BRCA2 mutations linked to breast cancer risk. However, <\/span>these mutations represent a small fraction<\/span><\/a> (from 2 percent to less than 0.1 percent, depending on ethnic background) of breast cancer cases in the United States. <\/span><\/p>\n

Further, only 5 to 10 percent of breast cancers in the United States are <\/span>thought to be hereditary.<\/span><\/a> As 23andMe\u2019s own website puts it: \u201cMost cases of cancer are not caused by the genetic variants in this report. A person could have a variant not included in this test, or could develop cancer for other reasons.\u201d 23andMe is not currently approved to test for thousands of genetic variants for breast cancer. So no matter what your result, you should <\/span>be sure to get your mammogram when the time is right.<\/span><\/a><\/p>\n

It May Cost Extra<\/b><\/h2>\n

At the moment, 23andMe\u2019s Health + Ancestry testing costs twice as much as its Ancestry service alone. If you are most interested in the Ancestry information, and are thinking of the health information as a \u201cnice to have,\u201d you\u2019ll probably want to weigh the pros and cons before ponying up an extra $100.<\/span><\/p>\n

If You Want Better Information, You May Need to Talk to Your Doctor<\/b><\/h2>\n

If you\u2019d like more comprehensive genetic testing, your doctor can order it, and your insurance may pay for it\u2014but <\/span>coverage is still spotty.<\/span><\/a> Check with your insurance company before ordering a test that could put you on the hook for thousands of dollars if your claim is denied.<\/span><\/p>\n

Conversely, the 23andMe test is available without a doctor\u2019s orders and is relatively low-cost. But your insurance definitely won\u2019t pay for it.<\/span><\/p>\n

So will you ever be able to get reliable and comprehensive genetic health testing at a cost you can afford?<\/span><\/p>\n

Health technology optimists <\/span>think that you will.<\/span><\/a> For one thing, they argue, the technology will only get better and cheaper. And as more and more people have their DNA tested, our global database of human genetic data will grow and improve, leading to better science and to treatments for diseases that are currently incurable.<\/span><\/p>\n

In the meantime, Hancock Health offers <\/span>a number of low-cost labs<\/span><\/a> that can help you manage your overall health. Also, doing what you can today to improve your health tomorrow is always a great idea. We\u2019ve got lots of <\/span>tips and ideas<\/span><\/a> that can help with that, too.<\/span><\/div>","protected":false},"excerpt":{"rendered":"

Mutations of the BRCA1 and BRCA2 genes can indicate increased risk of breast cancer. But they shouldn\u2019t be the only risk factors considered.<\/p>","protected":false},"author":6,"featured_media":8360,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_tec_requires_first_save":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"_tribe_blocks_recurrence_rules":"","_tribe_blocks_recurrence_description":"","_tribe_blocks_recurrence_exclusions":"","footnotes":""},"categories":[386],"tags":[],"service":[],"class_list":["post-8359","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":{"featured_image":8360,"page_title":"","sub_header":"","display_overlay":false},"yoast_head":"\nConsumer Genetic Testing and Breast Cancer Risk\u2014What the Tests Actually Tell Us - Hancock Health<\/title>\n<meta name=\"description\" content=\"Consumer genetic tests can show the risk of certain mutations that increase risk for breast cancer. 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