{"id":52666,"date":"2025-04-25T22:03:55","date_gmt":"2025-04-26T02:03:55","guid":{"rendered":"https:\/\/www.hancockhealth.org\/mayo-health-library\/limbic-predominant-age-related-tdp-43-encephalopathy-late\/"},"modified":"2026-02-04T12:07:07","modified_gmt":"2026-02-04T17:07:07","slug":"limbic-predominant-age-related-tdp-43-encephalopathy-late","status":"publish","type":"mayo","link":"https:\/\/www.hancockhealth.org\/es\/mayo-health-library\/limbic-predominant-age-related-tdp-43-encephalopathy-late\/","title":{"rendered":"Limbic-predominant age-related TDP-43 encephalopathy (LATE)"},"content":{"rendered":"<div class=\"container mx-auto   wordpress-block wordpress- core-\">\n<p>Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a type of dementia that affects memory, thinking and social skills.<\/p>\n<p>When people think about memory problems, Alzheimer&#8217;s disease comes to mind. But <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> is a different disease and has its own characteristics. Sometimes, people may have signs and symptoms of both <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> and Alzheimer&#8217;s disease.<\/p>\n<p>People with <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> have problems with memory but often have a slower rate of clinical change than people with Alzheimer&#8217;s disease. They may notice that over time it&#8217;s more difficult to remember facts, conversations and events. People with <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> may repeat themselves often, be forgetful and have trouble finding the right words during conversations. They may also have difficulty understanding words.<\/p>\n<p>Individuals with <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> may:<\/p>\n<ul>\n<li>Wander or get lost<\/li>\n<li>Make poor decisions<\/li>\n<li>Misplace things<\/li>\n<li>Have trouble driving<\/li>\n<li>Have difficulty keeping up with personal hygiene<\/li>\n<\/ul>\n<p>Eventually, someone with <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> has trouble with daily living activities such as dressing, cooking or paying bills. The mental decline in <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> is slower than in other forms of dementia. This causes a slow, rather than a rapid, worsening of symptoms.<\/p>\n<p><abbr title=\"Limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> usually affects older individuals, particularly those over age 80. Although advancing age is a risk factor for <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>, dementia is not part of the typical aging process.<\/p>\n<p>Genetics can also increase a person&#8217;s risk of developing <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>. At least five genes are associated with the risk of <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>. These same genes may also increase the likelihood of other forms of dementia.<\/p>\n<p>Currently, <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> can only be definitively diagnosed after death through an autopsy. But for people with symptoms, a diagnosis of <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> can be suggested through:<\/p>\n<ul>\n<li>Clinical history<\/li>\n<li><abbr title=\"Magnetic resonance imaging\">resonancia magn\u00e9tica<\/abbr> or fluorodeoxyglucose (FDG)-positron emission tomography (PET) findings<\/li>\n<li>Ruling out other causes <\/li>\n<\/ul>\n<p>Your health care provider may look for changes in the brain that can be caused by <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>. These can include signs of brain shrinkage (atrophy) and thinning of the parts of the brain responsible for memory formation. These changes can be seen on <abbr title=\"magnetic resonance imaging\">resonancia magn\u00e9tica<\/abbr> examination and on autopsies. Thinning seems to be a stronger indicator of how severe the disease is compared with atrophy.<\/p>\n<p>A buildup of the protein transactive response DNA-binding protein 43(TDP-43) may be another sign of <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>. This naturally occurring protein helps with nerve development. This buildup of <abbr title=\"transactive response DNA-binding protein 43\">TDP-43<\/abbr> is usually found in the part of the brain that supports memory, emotion, behavior and mood (limbic system). Right now, there isn&#8217;t a simple test to see whether a person has an excessive amount of <abbr title=\"transactive response DNA-binding protein 43\">TDP-43<\/abbr>. This would be discovered only with an autopsy.<\/p>\n<p>Another sign that could suggest a diagnosis of <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> is hardening and thickening of the walls of the arteries (arteriolosclerosis), which is common in people with <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>.<\/p>\n<p>If your health care provider suspects you might have <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>, they may suggest a mental status examination to find out how severe the cognitive impairment is.<\/p>\n<p>Researchers are working to find a simpler way to diagnose <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>, and other forms of dementia, to quickly identify these diseases. Researchers are working to develop a simple blood screening test for dementia, including <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>, but that is still being studied.<\/p>\n<p>There isn&#8217;t a definitive treatment or cure for <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr> yet.<\/p>\n<p>To help improve overall health and manage the symptoms of dementia, the World Health Organization (WHO) has made recommendations that include:<\/p>\n<ul>\n<li>Aumento de la actividad f\u00edsica<\/li>\n<li>Maintaining a healthy diet<\/li>\n<li>Decreasing alcoholic intake<\/li>\n<li>Avoiding smoking<\/li>\n<li>Treating chronic conditions such as hypertension, high cholesterol, depression, obesity and diabetes<\/li>\n<\/ul>\n<p>El <abbr title=\"Organizaci\u00f3n Mundial de la Salud\">WHO<\/abbr> also suggests increasing accessibility of health care and social workers to people with dementia and their caregivers.<\/p>\n<p>More studies are underway to discover better ways to diagnose and possibly treat <abbr title=\"limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy\">LATE<\/abbr>.<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>LATE causes symptoms similar to Alzheimer&#8217;s, but may progress more slowly.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","tags":[1686,1685,1682,1684],"class_list":["post-52666","mayo","type-mayo","status-publish","hentry","tag-anatomical-structure","tag-condition","tag-person-group-concept","tag-theme-of-focus","content_type-articles"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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